If you’re launching a moonshot, success depends on how you manage the trajectory of risk. When Stéphane Bancel became Moderna’s first CEO, the biotech start-up was chasing a way-out idea many experts thought was impossible. Stéphane built a culture of calculated risk-taking to create a platform for extraordinary leaps — one that enabled life-saving mRNA vaccines when Covid-19 struck.

Has Gopuff cracked the code of instant delivery — a field where even Amazon has struggled? Co-founder Yakir Gola talks about the challenge of owning the customer journey from app to warehouse to doorstep, and the reasons why being outside Silicon Valley is giving Gopuff a big advantage as it expands across the United States and around the world. Yakir talks with host Bob Safian about why moving fast is only one piece of the growth puzzle.

Charity Dean was one of the first public health officials to set the alarm on COVID. When she searched for a tool to forecast future bio threats, she realized that it didn’t exist yet. So she co-founded the Public Health Company, where she uses lessons from her government experiences, but without the same rules or limits. She speaks with Bob Safian about why all companies must be public health companies.

Gayle Smith is the CEO of the ONE Campaign, the advocacy group founded by U2’s Bono — and last year, she was tapped by the U.S. State Department to coordinate America’s COVID response and vaccine distribution globally. Her experience both inside and outside government gives her a distinctive outlook on how business can and should help on humanitarian issues, from Ukraine dislocation to climate change. She also shares lessons about effective advocacy: tactics pioneered by ONE that can be useful to any organization trying to generate impact.

Alyona Mysko, the CEO of a B2B startup in Ukraine called Fuelfinance, walks us through the lessons she’s learned while leading her company in wartime — sometimes working with her team from bomb shelters during the day. All of Ukraine is running like a startup now, she says: Each citizen takes the initiative to pick up what needs to be done.

Eric Friedrichsen, the CEO of Emburse, a B2B software provider, has navigated risks and costs to meet the needs of their tech contractors based in Ukraine — like offering to relocate families, and funding housing costs for colleagues taking refuge in Poland. These choices haven’t come without obstacles. But the benefits are moral, communal, and quantifiable.

Russia’s invasion of Ukraine, and the sanctions that followed, radically impacted supply chains around the world. Jennifer Bisceglie, CEO of Interos, a risk-management firm focused on supply chains, has seen her company’s risk dashboards light up in new and far-reaching ways. Meanwhile, a more sophisticated supply chain is coming together in real-time.

Watching the news out of Ukraine, Tokunbo Koiki saw reports of Black students struggling to flee the country. Tokunbo, an entrepreneur and social worker, linked up with two strangers, Patricia Daley and Korrine Sky, to build an aid organization for Black refugees — in a single weekend. Black Women for Black Lives helped some 1,200 Black students with direct assistance, a perfect illustration of how entrepreneurial thinking can mobilize action faster than you think it can.

“My big call to action would be to support existing organizations,” says Susy Schöneberg, the founder and head of Flexport.org, the nonprofit arm of the logistics firm Flexport. Schöneberg and her team are organizing complex shipments of relief goods to Ukrainian refugee sites across Eastern Europe; she breaks down how her organization has been safely managing the flow of goods toward displaced refugees and the best way you can get involved — as a citizen or company. She leaves us with a lesson that applies to any crisis: joining together can produce far better results than trying to do it alone.

“We have to assume that cyberattacks will happen,” says Bipul Sinha, CEO of the cybersecurity firm Rubrik. State-sponsored actors and cybercriminals are both heightened threats now, and cybersecurity tactics must learn to counter them. Bipul shares what we can do to protect ourselves — starting with basic cyber hygiene.

Russia’s invasion of Ukraine presents a new level of disruption to an already fragile global trade system. Sara Menker, the CEO of Gro Intelligence, offers a window into the shifts across all parts of the economy. She shares what we need to understand about Russia’s trade with China and largely overlooked impacts in the Middle East.

Tjada D’Oyen McKenna is the CEO of Mercy Corps, an NGO on the front lines of the Ukrainian crisis. They began scenario-planning well in advance of Russia’s aggression, and they’re now deploying food, cash, and social services to refugees in need. She shares their strategy — and how they’re also keeping focus on other struggles around the world.