When the FDA blessed Upside Foods’ grown-from-cells chicken as safe to eat, it was a coming-of-age moment for cultivated meat. Upside founder and CEO Dr. Uma Valeti shares his journey of convincing skeptics, landing investors from Bill Gates to food giants Tyson and Cargill, and building a collaborative partnership with the FDA and USDA. Plus, his lessons on leadership from a career in cardiology and what it will take to convert consumers to a never-before-seen product.

Running a business can be a lonely job. The long hours, the existential threats — it can feel like the weight of the entire company is on your back. That’s where the transformative power of co-founders comes in. Co-founders provide more than added manpower; they bring fresh perspectives and talents that help businesses conquer problems at speed. And the co-founder effect extends beyond the people who started the company: The lessons hold true for every team member that contributes in a foundational way. The more voices you add, the more resilience you build in yourself, and your organization.

Hybrid, remote, in-person, a little bit of everything? Work has transformed into a giant experiment. Priya Parker, expert facilitator and author of The Art of Gathering: How We Meet and Why It Matters, shares her advice on how to manage the new hybrid workplace. Where to start? Focus first, she suggests, on making your meetings better.

Partnerships can be the secret weapon to rocketing your company to the next level. That’s what Cathy Zoi discovered when she became the CEO of charging station network, EVgo. Whether it be partnering with grocery and department stores, or aligning with the Tesla customer-base, targeting allies and collaborators are a crucial catalyst for how EVgo has grown to become the nation’s largest public EV charging network.

When it comes to racial justice, many companies and organizations haven’t matched their reality to their words. Rashad Robinson, the president of Color of Change, the largest online racial justice organization in the U.S., is holding major corporations accountable. Hear Rashad talk through the difficulties of changing systems from Hollywood, Silicon Valley, to Washington DC, getting help from President Barack Obama, and what business leaders can do to actively change racial injustice.

Creative energy is the raw fuel of entrepreneurship, but if you fail to direct that energy effectively, you risk chasing multiple ideas and delivering none. Tony Fadell learned this lesson time and again through his journey to co-create the iPod, iPhone, and Nest. He shares how he struck the tricky balance of channeling his creative experimentation into world-changing products.

What’s the difference between an activist brand and an active brand? Impossible Foods CEO Peter McGuinness says that acting on your values defines a business — from climate change to Roe v. Wade. To unleash the next wave of growth for plant-based meat purveyor Impossible, McGuiness is rethinking how the whole category presents itself, taking aim at what he calls “safe and lame” approaches, partnering with the likes of Billie Eilish, and targeting the $1.4 trillion global meat industry.

When a tech nonprofit competes against a $2 billion incumbent dominating the market, its odds are slim. But Zo Orchingwa took that bet, founding Ameelio, believing that access to communication and education for the incarcerated is needed for their future success. Ameelio is on a quest to partner with every prison district in the country until one day, it scales enough to be redundant.

The first stage of building up a business is to break things down. Michael Dell started a computer company in his dorm room by cracking open some early IBM PCs and figuring out what he could do better, faster, and cheaper. Then he did the same thing to the entire model of computer sales. Learn from Dell how to revolutionize an industry — using deconstruction to gain insight your competitors lack, and then building something bigger and better.

For Reid Hoffman, the way to live a meaningful and productive life is to focus on one key area: friendships. Speaking at Vanderbilt University’s 2022 commencement, he shares four lessons on why friendships are crucial for helping us achieve our potential and enact meaningful change.

It’s easy to have a grand idea; putting that plan into action is not. Victoria Yampolsky conceived of a global concert in support of Ukraine. Without any experience in entertainment or international aid, she shares how she didn’t accept “no” for an answer in her quest to book big-name guests like Pink Floyd and negotiate a streaming deal — to pursue a fundraising goal of $10 million.

If you’re launching a moonshot, success depends on how you manage the trajectory of risk. When Stéphane Bancel became Moderna’s first CEO, the biotech start-up was chasing a way-out idea many experts thought was impossible. Stéphane built a culture of calculated risk-taking to create a platform for extraordinary leaps — one that enabled life-saving mRNA vaccines when Covid-19 struck.