Massive change isn’t something you can brute-force — you need to ignite buy-in, again and again, up and down your organization. Because even if your changes will make things more fun, more interesting, and more profitable, you’re going to face defiance and inertia until you clue everyone in. That’s what Bill Ford learned while working to remake Ford Motor Company as an environmental powerhouse — against surprising internal and even national-level resistance.

Russia’s invasion of Ukraine, and the sanctions that followed, radically impacted supply chains around the world. Jennifer Bisceglie, CEO of Interos, a risk-management firm focused on supply chains, has seen her company’s risk dashboards light up in new and far-reaching ways. Meanwhile, a more sophisticated supply chain is coming together in real-time.

Russia’s invasion of Ukraine presents a new level of disruption to an already fragile global trade system. Sara Menker, the CEO of Gro Intelligence, offers a window into the shifts across all parts of the economy. She shares what we need to understand about Russia’s trade with China and largely overlooked impacts in the Middle East.

Tjada D’Oyen McKenna is the CEO of Mercy Corps, an NGO on the front lines of the Ukrainian crisis. They began scenario-planning well in advance of Russia’s aggression, and they’re now deploying food, cash, and social services to refugees in need. She shares their strategy — and how they’re also keeping focus on other struggles around the world.

GM is working on two daunting goals: an all-electric vehicle future, and building its rep as the world’s most inclusive company. Gerald Johnson, EVP of manufacturing and sustainability at General Motors, helped lead GM’s COVID-19 response; he’s now tackling these next, twin challenges.

It may appear off-brand for Betterment, a digital investment adviser, to acquire a cryptocurrency investing platform. But as CEO Sarah Levy says, Betterment approached this volatile space with long-term thinking. Levy, who became CEO in the midst of the pandemic, offers perspective on how new digital finance platforms are shifting the norms of the industry.

Ken Frazier, the longtime CEO of Merck, was one of the few Black CEOs at the top of corporate America. Now as an adviser at General Catalyst and co-founder of the social impact organization OneTen, he’s re-shaping how business addresses racial and health equity. There’s an important role business can play, he says, by stressing our commonality.

As the global chip shortage unfolded in 2021, Qualcomm’s engineers quickly redesigned their products – an effort that tapped into “every possible capacity we could find,” says CEO Cristiano Amon. Their story is a great lesson in how an established company can and must move with the speed of a startup.

The Drone Racing League has built a fanbase previously untapped by pro sports. President Rachel Jacobson, formerly an NBA executive, calls their fans “techsetters” – young, enthusiastic, techy fans who are “invested in what the future looks like.” It’s a demographic that loves the league’s positioning that intersects sports, entertainment, and technology. As Rachel says, companies that aren’t planning for future demographics of consumers will “age out really quickly.”

Faced with long odds, how do you keep your team motivated and moving forward? Alexis McGill Johnson is focused on building hope. As president of Planned Parenthood, Johnson is preparing for the U.S. Supreme Court to overturn Roe v. Wade — and modeling a sense of relentlessness for her team, so they too can be fearless.

Sir Jeremy Farrar is UK’s pre-eminent scientific authority on Covid-19 and the chief executive at the research foundation Wellcome Trust. He shares the latest learnings of the Omicron variant – and offers a framework for handling the uncertainty. He shares two leadership lessons he’s learned during the pandemic: find time for yourself, and take warnings seriously.

“Go for the megatons.” That’s John Doerr’s recommendation for how we need to combat the existential threat of climate change. Doerr, a venture capitalist and author of the new book Speed & Scale, discusses decarbonization, what he calls “the greatest economic opportunity of the next century.” Business plays a critical role in advancing that movement.